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In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 g) and vitamin B 12 (100 g) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

The American Journal of Clinical Nutrition, 121 (1), 5-13

Expect headline-sensitive gap/drive behavior around filings, FDA milestones, and cross-trial comps

What side effects should I expect

Functional divergence in the glutathione transferase superfamily in plants identification of two classes with putative functions in redox homeostasis in Arabidopsis thaliana

These findings demonstrate that sulforaphane robustly activates NRF2 in the cerebellum and peripheral tissues, protecting them from oxidative stress and leading to a reduction in autism-like behaviors (Nadeem et al., 2019)